"Runnin' through the 6 with my woes" is a line from Drake's Know Yourself song. The 6 in this line is referring to 416, one of 3 area codes for the city of Toronto. Woes is short for the slang "Whoadie" which means close friends/associates. In essence, Drake's line is saying that he's walking through the 416 (6) with his buddies (whoadies).